Dr. Brianne Guilford
Associate Professor
(e-mail)
Education:
PhD, 2013, Anatomy and Cell Biology, University of Kansas Medical Center
MA, 2004, Exercise Physiology, University of Missouri-Columbia
BS, 2000, Biology and Psychology, Northwest Missouri State University
Specialization:
Diabetic neuropathy, impact of diet and exercise on cellular mechanisms underlying neurodegenerative disease, mitochondrial dysfunction, diabetes
Phone:
618-650-5678
Office:
2608 Vadalabene Center
About Dr. Guilford
Dr. Guilford’s research expertise is in basic biomedical science with focus on investigating mechanisms underlying peripheral nervous system disorders. In addition, Dr. Guilford’s research experience includes human exercise training, weight management, and children’s physical activity interventions. Dr. Guilford has several peer reviewed publications and has presented her research over the past 10 years at numerous national and international conferences including the American College of Sports Medicine (ACSM), Integrative Biology of Exercise, Peripheral Nerve Society, Society for Neuroscience, and Diabetic Neuropathy Study Group. She is a Certified Health Fitness Specialist through the American College of Sports Medicine. Dr. Guilford teaches courses in Advanced Exercise Physiology, Exercise Endocrinology, Exercise for Special Populations, and Exercise Physiology.
Research Profile:
Dr. Guilford’s research interest involves investigating how diet, obesity, dyslipidemia impact the development of neurodegenerative disease. In addition, Dr. Guilford is interested in how exercise can prevent and treat diabetic neuropathy. Her current work is focused on the effects of omega-3-fatty acids on neuropathy. This project includes assessing inflammatory factors and nerve fiber density in the skin of mice fed a high-lard or high fat fish oil fat diet. In addition, she is currently studying the prevalence of the Male Athlete Triad in SIUE NCAA athletes. The triad is characterized by having one of the following conditions: low energy availability, decreased bone mineral density, and/or reduced reproductive hormones. The prevalence of the Female Athlete Triad has been well studied in female athletes, but the similar condition in males has long been ignored, thus warranting further research.
Publications: (list)
Grote CW, Wilson NM, Katz NK, Guilford B.L., Ryals JM, Novikova L, Stehno-Bittel L, Wright DE. Deletion of the insulin receptor in sensory neurons increases pancreatic insulin levels. Exp Neurol. 2018 Apr 9. pii: S0014-4886(18)30086-4. doi: 10.1016/j.expneurol.2018.04.002. PubMed PMID:29649429.
Guilford, B.L., Leey, J.A., Strassels, S.A., Rai, A., and Herndon, C.M. Is impaired hypoglycemia awareness associated with obstructive sleep apnea in diabetic patients? Diab, Obes, and Metab Disorders Open Access. April 2018: 4:16-23.
Guilford, B.L., Parson, J.C., Grote, C.W., Vick, S.N., Ryals, J.M., and Wright, D.E. Increased FNDC5 is associated with insulin resistance in high fat-fed mice. Physiological Reports. April 2017: 5 (13): e13319.
Guilford, B.L., Ryals J.M, E Lezi, Swerdlow R.H., and Wright DE. Dorsal root ganglia mitochondrial biochemical changes in non-diabetic and streptozotocin-Induced Diabetic Mice Fed with a Standard or High-Fat Diet. J. Neurology and Neuroscience. Mar 2017: 8 (2): 180.
Guilford, B.L. and Wright, D.E. Chewing the fat: Genetic approaches to model dyslipidemia-induced diabetic neuropathy in mice. Experimental Neurology 2013; 248: 504-508. PMID: 23933575
Groover, A.L., Ryals, J.M., Guilford, B.L., Wilson, N.M., Christianson, J.A., and Wright, D.E. Exercise-mediated improvements in painful neuropathy associated with pre-diabetes in mice. Pain 2013; 154 (12): 2658-2667. PMID: 23932909.
Levant, B., Ozias, M.S., Guilford, B.L., and Wright. D.E. Streptozotocin-induced diabetes partially attenuates the effects of a high-fat diet on liver and brain fatty acid composition in mice. Lipids 2013; 48(9): 939-948. PMID: 28933338.
Guilford, B.L., Ryals J.M., Wright, D.E. Phenotypic changes in diabetic neuropathy induced by a high-fat diet in diabetic C57Bl/6 mice. Experimental Diabetes Research 2011; 2011:848307. PMID: 2214490.
Saunders, R.R., Saunders, M.D., Donnelly, J.E., Smith, B.R., Sullivan, D.K., Guilford, B.L., and Rondon, M.F. Evaluation of an approach to weight loss in adults with intellectual or developmental disabilities Intellectual and Developmental Disabilities, 2011; 49(2): 103-112. PMID: 21446873.
Rector, R.S., Turk, J.R., Sun, G.Y., Guilford, B.L., Toedebusch, B.W., McClanahan, M.W., and Thomas, T.R. Short-term lifestyle modification alters circulating biomarkers of endothelial health in sedentary overweight adults. Applied Physiology, Nutrition, and Metabolism 2006; 31(5): 512-517. PMID: 17111005.
Altena, T.S., Michaelson, J.L., Ball, S.D., Guilford, B.L., and Thomas, T.R. Lipoprotein subfraction changes after continuous or intermittent exercise training. Medicine Science Sports and Exercise 2006; 38(2): 367-372. PMID: 16531908.
